HMLab

Organic Chemistry Research at Fresno State

Home The Team Dr. Muchalski Research Publications Teaching
updated: 2024-12-06

© Hubert Muchalski 2015–2024.

Refereed Publications

  1. Pisor, J. W.‡; Garcia, I. C.†; Mamo, K.†; Muchalski, H. Synthesis of benzofurans from THP acetals of 2-alkynylphenols catalyzed by gold(I)-NHC complexes In Preparation
  2. Ilyer, K. S.; Yirak, J. R.†; Muchalski, H.; Lipshutz, B. H. Synthesis of S,S-Di(pyridin-2-yl)carbonodithioate (DPDTC) for the Reduction of Carboxylic Acids Org. Synth, 2024, 101, 274-294. (http://www.orgsyn.org/demo.aspx?prep=v101p0274)
  3. Closser, K. D.; Hawker, M. J.; Muchalski, H. Quantized Grading: An Ab Initio Approach to Using Specifications Grading in Physical Chemistry. J. Chem. Educ. 2024, 101 (2), 474–482. (https://doi.org/10.1021/acs.jchemed.3c00872).
  4. Le, Q.; Dillon, C. C.; Lichtenstein, D.A..† Pisor, J.W.; Gold(I)–NHC-catalysed synthesis of benzofurans via migratory cyclization of 2-alkynylaryl benzyl ethers. Org. Biomol. Chem. 2020, 18, 8186–8191; DOI: 10.1039/D0OB01538E.
  5. Rajaram,P.‡;Rivera,A.M.†;Muthima,K.†Olveda,N.†;Muchalski,H.;andChen,Q.- C. Second-Generation Androgen Receptor Antagonists as Hormonal Therapeutics for Three Forms of Prostate Cancer Molecules 2020, 20, 2448; DOI:10.3390/molecules25102448.
  6. Dillon, C. C.†; Keophimphone, B.†; Sanchez, M.†; Kaur, P.†; Muchalski, H., Synthesis of 2-substituted benzo[b]thiophenes via gold(i)–NHC-catalyzed cyclization of 2-alkynyl thioanisoles. Org. Biomol. Chem. 2018, 16, 9279-9284. doi:10.1039/C8OB02196A
  7. Muchalski, H., Site-specific synthesis and application of Deuterium-Labeled sterols. Arkivoc 2017 , 507-533. DOI:10.3998/ark.5550190.p009.755
  8. Lamberson, C. R.; Muchalski, H.; McDuffee, K. B.†; Tallman, K. A.; Xu, L.; Porter, N. A., Propagation rate constants for the peroxidation of sterols on the biosynthetic pathway to cholesterol. Chem. Phys. Lipids 2017, 207, Part B, 51-58. DOI: 10.1016/j.chemphyslip.2017.01.006.
  9. Muchalski, H.; Levonyak, A. J.†; Xu, L.; Ingold, K. U.; Porter, N. A., Competition H(D) Kinetic Isotope Effects in the Autoxidation of Hydrocarbons. J. Am. Chem. Soc. 2015, 137, 94-97. DOI:10.1021/ja511434j.
  10. Muchalski, H.; Xu, L.; Porter, N. A., Tunneling in tocopherol-mediated peroxidation of 7-dehydrocholesterol. Org. Biomol. Chem. 2015, 13, 1249-1253. DOI:10.1039/C4OB02377C.
  11. Lamberson, C. R.; Xu, L.; Muchalski, H.; Montenegro-Burke, J. R.; Shmanai, V. V.; Bekish, A. V.; McLean, J. A.; Clarke, C. F.; Shchepinov, M. S.; Porter, N. A., Unusual Kinetic Isotope Effects of Deuterium Reinforced Polyunsaturated Fatty Acids in Tocopherol-Mediated Free Radical Chain Oxidations. J. Am. Chem. Soc. 2014, 136, 838-841. DOI:10.1021/ja410569g.
  12. Giurg, M.; Muchalski, H.; Kowal, E., Oxofunctionalized trans-2-carboxycinnamic acids by catalytic domino oxidation of naphthols and hydronaphthoquinones. Synth. Commun. 2012, 42, 2526-2539. DOI:10.1080/00397911.2011.561945.
  13. Muchalski, H.; Johnston, J. N. Aziridination. In Science of Synthesis: Stereoselective Synthesis; de Vries, J. G., Ed.; Thieme: Stuttgart, 2011 Vol. 1, pp 155–184.
  14. Troyer, T.; Muchalski, H.; Hong, K.; Johnston, J., Origins of Selectivity in Bronsted Acid-Promoted Diazoalkane-Azomethine Reactions (The Aza-Darzens Aziridine Synthesis). Org. Lett. 2011, 13, 1790-1792. DOI: 10.1021/ol200313m.
  15. Muchalski, H.; Doody, A. B.; Troyer, T. L.; Johnston, J. N., Preparation of Isopropyl 2-Diazoacetyl(Phenyl)Carbamate. Org. Synth. 2011, 88, 212-223.
  16. Muchalski, H.; Hong, K.; Johnston, J., Bronsted acid-promoted azide-olefin [3+2] cycloadditions for the preparation of contiguous aminopolyols: The importance of disiloxane ring size to a diastereoselective, bidirectional approach to zwittermicin A. Beilstein J. Org. Chem. 2010, 6, 1206-1210. DOI: 10.3762/bjoc.6.138.
  17. Johnston, J.; Muchalski, H.; Troyer, T., To Protonate or Alkylate? Stereoselective Bronsted Acid Catalysis of C-C Bond Formation Using Diazoalkanes. Angew. Chem. Int. Ed. 2010, 49, 2290-2298. DOI: 10.1002/anie.200904828.
  18. Troyer, T. L.; Muchalski, H.; Johnston, J. N., Bronsted acid activation of alpha-diazo imide: a syn-selective glycolate Mannich reaction. Chem. Commun. 2009 , 6195-6197. DOI: 10.1039/b913785h.
  19. Adkins, C. T.; Muchalski, H.; Harth, E., Nanoparticles with Individual Site-Isolated Semiconducting Polymers from Intramolecular Chain Collapse Processes. Macromolecules 2009, 42, 5786-5792. DOI: 10.1021/ma9007913.
  20. Niswender, C. M.; Lebois, E. P.; Luo, Q. W.; Kim, K.; Muchalski, H.; Yin, H. Y.; Conn, P. J.; Lindsley, C. W., Positive allosteric modulators of the metabotropic glutamate receptor subtype 4 (mGluR4): Part I. Discovery of pyrazolo 3,4-d pyrimidines as novel mGluR4 positive allosteric modulators. Bioorg. Med. Chem. Lett. 2008, 18, 5626-5630. DOI: 10.1016/j.bmcl.2008.08.087.
  21. Giurg, M.; Kowal, E.; Muchalski, H.; Syper, L.; Mlochowski, J., Catalytic Oxidative Domino Degradation of Alkyl Phenols Towards 2-and 3-Substituted Muconolactones. Synth. Commun. 2008, 39, 251-266. DOI: 10.1080/00397910802369687.
  22. Daniels, R. N.; Kim, K.; Lebois, E. P.; Muchalski, H.; Hughes, M.; Lindsley, C. W., Microwave-assisted protocols for the expedited synthesis of pyrazolo 1,5-a and 3,4-d pyrimidines. Tetrahedron Lett. 2008, 49, 305-310. DOI: 10.1016/j.tetlet.2007.11.054
  23. Croce, T. A.; Hamilton, S. K.; Chen, M. L.†; Muchalski, H.; Harth, E., Alternative o-quinodimethane cross-linking precursors for intramolecular chain collapse nanoparticles. Macromolecules 2007, 40, 6028-6031. DOI: 10.1021/ma071111m.